Description: While the diosgenin found in wild yam created quite a stir in the 1990s as a cure for menopausal disorders and other symptoms of aging in women, the plant itself has no proven hormonal action, nor have any studies shown it to be effective in treating hormone related disorders. It is true that diosgenin can be converted into steroidal compounds, which are then used in the chemical synthesis of progesterone, but this is in the laboratory—not in the human body. There is essentially no scientific evidence of wild yam’s effectiveness in treating menopausal symptoms or osteoporosis. Although many individuals claim relief of symptoms such as vaginal dryness with the use of progesterone creams, some of which contain an extract of Dioscorea villosa , no well-designed studies have evaluated these creams. Moreover, many products that claim to contain natural progesterone actually contain synthetic medroxyprogesterone acetate (MPA).